Publications
Substantial Zoonotic Bacterial Pathogen Caused Infections: A Review
Mar 26, 2025Journal Scholars Academic Journal of Biosciences
DOI https://doi.org/10.36347/sajb.2025.v13i03.008
Issue 3
Volume 13
Zoonotic diseases are widespread worldwide and represent an important source of infection transmitted directly or indirectly to humans. This article aimed to review the available literature on bacterial pathogens in wild and domestic animals and their significant public health concerns. The key to the transmission methods for infection with zoonotic bacterial pathogen were either by food or water borne, direct or indirect contact, aerosol inhalation, scratches or bites, animal’s secretions. Although infected animals may be asymptomatic, they can transmit the infection to humans. This can also cause economic losses due to high animal mortality rates or reduced production. Regarding its impact on public health, it was concluded that zoonoses cause high morbidity of severe human infections and even serious complications worldwide.
Endoscopic Transethmoid Drainage of Frontal Lobe Brain Abscess: Rare Case Report
Mar 25, 2025Journal SAS Journal of Medicine
DOI http://dx.doi.org/10.36347/sasjm.2025.v11i03.016
Issue 3
Volume 11
A frontal lobe abscess is a common life-threatening brain emergency, with critical treatment relying on a combination of drainage and parenteral antibiotic medication. A 14-year-old female with type 1 diabetes mellitus was referred from the Department of Neurosurgery with a history of right-sided facial twitching repeating every 5 minutes and accompanied with pyrexia. An MRI scan revealed a 2 x 2 cm abscess in the frontal lobe, attached to skull base. Intravenous antibiotics were started, but after 12 hours, her consciousness deteriorated, therefore the abscess was urgently drained successfully via endoscopic transnasal transethmoid route. The skull base window was repaired using fat, tensor fascia lata and duraseal. The postoperative recovery was uneventful, with no cerebrospinal fluid leakage or meningitis, and patient's condition was satisfactory. Follow-up with an immediate CT scan MRI scan 3 months later showed no manifest of abscess returning. It was concluded that the transnasal transethmoid approach has the advantage of allowing the abscess to be identified and drained definitively without intra-cerebral penetration.
Evaluation of Proinflammatory Cytokines in Arsenic Induced Hepatotoxicity In Vivo
Dec 4, 2024Journal Journal of Animal Health and Production
DOI http://dx.doi.org/10.17582/journal.jahp/2024/12.s1.196.201
Arsenic (As), an environmental pollutant, induces hepatic oxidative damage that leads to liver disease. Also, it may be associated with immune-related disorders at high doses. This study aimed to evaluate the As-induced acute hepatotoxicity and the role of immune response through inflammatory cytokines in laboratory rats. Eighteen adult male rats were employed in present study, and they were set into three groups (n = 6/group). First group acted as control (CON) without any treatment, while other two groups were exposed to sodium arsenite orally at a single dose (13 mg/kg) Animals were sacrificed at 1 day and 7 days after exposure of As, and referred as AS-1 and AS-7 groups, respectively. Following that, each rat’s serum was taken for the required biochemical assays, and its liver was removed to assess oxidative stress markers. Comparing treated versus untreated rats, the results showed that AS exposure significantly raised malondialdehyde levels in liver tissue while clearly inhibiting the level of total antioxidants. Furthermore, a time-dependent significant increase in serological concentrations of hepatic enzymes and pro-inflammatory cytokines was noted in comparison to control rats. It was concluded that arsenic-induced hepatotoxicity and pro-inflammatory cytokines response are associated with a time-dependent increasing.