Investigation of lipocalin2 and calprotectin in Ulcerative colitis patients

May 29, 2019

Journal Journal of pharmaceutical science and research

publisher JPSR

Issue 11

Volume 2

Ulcerative colitis (UC) is a chronic inflammatory disease of the colon. The present study included a total of 75 patients with ulcerative colitis and 35 apparently healthy subjects, all samples were tested by enzyme linked immunosorrbent assay (ELISA).Serum LCN2 concentrations (104.62ng/ml) of ulcerative colitis patients were significantly higher than the healthy control group (49.58ng/ml). The results of Calprotectin in stool revealed that concentrations in ulcerative colitis patients (208.7ng/ml) were higher than healthy controls with significant differences.Serum level of Calprotectin represented that concentrations in ulcerative colitis cases (54.3ng/ml) were higher than healthy controls with significant differences. The severity of disease had significant effect on the concentration of serum levels of LCN2 and Calprotectin in ulcerative colitis patients, but no significant effect of severity on the concentration of fecal Calprotectin

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