Publications
Renal Histological Effects of Artificial Sweeteners in Albino Rats
Apr 15, 2025Journal International Journal of Environmental Sciences
Publisher Asian Society for Scientific Publishing and Dissemination
DOI https://doi.org/10.64252/1qtw4p85
Issue Vol. 11 , NO 2s, 2025
Volume Vol. 11
The study was conducted to evaluate the effect of different doses of artificial sweeteners on the kidneys of male and female rats, and to identify the potential renal tissue damage effects. The study included (15) male and female rats that were subjected to the necessary laboratory conditions for 30 days. They were divided as follows: a control group; a group that was given one sweetener tablet dissolved in 2 cc of water at a rate of two doses of 1 cc for a month; and a group that was given two sweetener tablets dissolved in 4 cc of water at a rate of four doses of 1 cc for a month. Histological examination of the kidneys of rats treated with one and two sweeteners revealed tissue lesions in the cortex, fragmentation and atrophy of the glomerulus, expansion of the capsular or urinary space, desquamation of the epithelium lining the parietal layer of Bowman's capsule, and desquamation of the epithelial cells lining several urinary tubules. Hematomas were also present in some sections. The medulla also showed extensive hemorrhage around the urinary tubules and partial desquamation of the epithelium lining several urinary tubules. Our study concluded that the use of sweeteners containing sodium cyclamate and sodium saccharin is unsafe for the kidney and may cause renal tissue lesions over the long term.
Study genotoxicity of ciprofloxacin in white rats
Jan 16, 2020Journal Indian Journal of Forensic Medicine & Toxicology
Publisher Mustafa Ahmed Shihab1, WAJDI Sabeeh Sadek1
DOI https://doi.org/10.37506/ijfmt.v14i1.162
Issue 14(1), 871-876
Volume Vol. 14 No. 1
The genotoxic and cytotoxic effects of ciprofloxacin drug on the bone marrow of white male rats were assessed by the Micronucleus test (MN) in polychromatic Erythrocytes (PCEs). The DNA damage was assessed by the Comet assay technique in bone marrow, liver and spleen. The white male rats were administered by oral gavage of single doses (93.5), (187) mg.kg-1 of body weight with twice a day for 7 consecutive days, while the negative control group was administered distilled water. The results showed a significant increase in the number of micronuclei corresponding to the duration of exposure., there was a change in the percentage of immature erythrocytes in bone marrow. This increased with an increase in treatment duration. As for the number of immature erythrocytes containing micronuclei, there was a significant increase corresponding to the treatment duration. When using the comet assay technique, the values of DNA damage increased in a dose-related manner