Publications
Renal Histological Effects of Artificial Sweeteners in Albino Rats
Apr 15, 2025Journal International Journal of Environmental Sciences
Publisher Academic Science Publications and Distributions
DOI 10.5281/zenodo.15623613
Issue 11
Volume 2
The study was conducted to evaluate the effect of different doses of artificial sweeteners on thekidneys of male and female rats, and to identify the potential renal tissue damage effects. The studyincluded (15) male and female rats that were subjected to the necessary laboratory conditions for 30 days.They were divided as follows: a control group; a group that was given one sweetener tablet dissolved in 2 ccof water at a rate of two doses of 1 cc for a month; and a group that was given two sweetener tabletsdissolved in 4 cc of water at a rate of four doses of 1 cc for a month. Histological examination of thekidneys of rats treated with one and two sweeteners revealed tissue lesions in the cortex, fragmentation andatrophy of the glomerulus, expansion of the capsular or urinary space, desquamation of the epitheliumlining the parietal layer of Bowman's capsule, and desquamation of the epithelial cells lining several urinarytubules. Hematomas were also present in some sections. The medulla also showed extensive hemorrhagearound the urinary tubules and partial desquamation of the epithelium lining several urinary tubules. Ourstudy concluded that the use of sweeteners containing sodium cyclamate and sodium saccharin is unsafe forthe kidney and may cause renal tissue lesions over the long term.
Evaluation of the hepatoprotective role of ethanolic Saussurea lappa root extract in female rats experimentally exposed to propylthiouracil
Jan 29, 2023Journal Tikrit Journal of Pure Science
Publisher Tikrit Journal of Pure Science
DOI 10.4308/hjb.30.6.1054-1060
Issue 6
Volume 27
Propylthiouracil (PTU) is often used to produce experimental hypothyroidism. In general, PTU generates hepatotoxicity, albeit with dissimilar incidence rates of hepatotoxicity. This study examined the hepatoprotective effects of Saussurea lappa root ethanol extract on experimentally induced hepatotoxicity in female rats. For this study, 25 adult female albino rats were placed into five equal groups: control, PTU, post treated with S. lappa extract, co-administered PTU with S. lappa extract 300mg/kg, and post-treated with levothyroxine. Serum gamma-glutamyl transferase (GGT) activity, total protein, thyroid hormones (T3, T4, and TSH), and oxidative stress parameters (catalase, superoxide dismutase, reduced glutathione, and lipid peroxidation levels) were measured. The liver tissue underwent histological examination. Current findings revealed that S.lappa ethanol root extract significantly improved hepatotoxicity as evidenced by reversal of various biochemical and histopathological changes in female rats. Current study has shown that this promising impact may be due to the antioxidant and free radical scavenging characteristics of S.lappa constituents.