Publications
Ltb4r gene expression in chronic myeloid leukemia in Iraq
May 30, 2023Journal Iraqi Journal of Science
Publisher Baghdad University
DOI https://doi.org/10.24996/ijs.2023.64.5.9
Issue 5
Volume 64
The current study was carried out to explore gene expression of the LTB4R gene with the development of chronic myeloid leukemia (CML) in Iraqi patients. The differences in the expression of this gene between patients and healthy controls were studied. The correlation of gender and age with CML patients compared with controls was included as well as the correlation of gene expression folding 2-ΔΔCt of LTB4R with clinical parameters (WBC, RBC, haemoglobin, platelets, and BCR-ABL gene). Results revealed significant increases in the mean of gene expression level (ΔCt) of patient groups compared to the corresponding ΔCt means in the healthy control group, the gene expression folding (2-∆∆ Ct) of the LTB4R gene reflects significant differences in the expression showed the highest level in CML patients which reached to (9.12), no significant differences were exhibited according to age and gender between CML patients and control. The study revealed a non-significant positive correlation between LTB4R gene expression level with both the BCR-ABL gene and WBC. Our results concluded that the LTB4R gene expression level could act as a marker for the prognosis of CML.
CASPASE 9 GENE EXPRESSION AND CASPASE 9 PROTEIN IN CHRONIC MYELOID LEUKEMIA IN IRAQ.
Oct 25, 2022Journal Iraqi Journal of Agricultural Sciences
Publisher Baghdad University
Issue 5
Volume 53
The following study was carried out to investigate gene expressions of the CASPASE 9 gene and CASPASE 9 protein with the development of chronic myeloid leukemia (CML) in Iraq. The differences in the expression of this gene between patients and healthy controls were included. The correlation of age and gender with CML occurrence comparing with controls was studied. Results showed significant increases in the mean of gene expression level (ΔCt) of patient groups compared to the corresponding ΔCt means in control group, also the gene expression folding (2-∆∆ Ct) of CASPASE 9 gene reflect significant differences in the expression showed the highest level in CML patients which reached to (16.19), the level of CASPASE 9 protein was (1.025 ng/ml) in patients with CML compared to control groups with significant differences. On the other hand no significant differences were exhibited according to age and gender between CML patients and control, this result suggest that CML can affect all ages and occur in both male and females.