Bachelor of General Chemistry, Mosul University, Iraq

Sep 1, 1998 - Jun 30, 2002

Master of Biochemistry, Mosul University, Iraq

Sep 1, 2003 - Jun 30, 2005

PhD in Biochemistry, Mosul University, Iraq

Sep 1, 2010 - Jun 30, 2013

المعهد التقني الموصل [مسؤول الشعبة العلمية]

Sep 12, 2018 - Oct 21, 2020

المعهد التقني الموصل [معاون العميد للشؤون العلمية والطلبة]

Oct 1, 2020 - Sep 16, 2021

الكلية التقنية الزراعية الموصل [معاون العميد للشؤون الادارية والمالية]

Jan 31, 2023 - May 3, 2023

الكلية التقنية الزراعية الموصل [عميد]

Aug 16, 2022 - Present

Effect of Bioactive Compounds Derived from Taraxacum Officinale on Biochemical and Hematological Traits of Ethylene Glycol Intoxicated Rabbits

Apr 18, 2024

Journal IOP Conference Series: Earth and Environmental Science

publisher Institute of Physics

DOI 10.1088/1755-1315/1371/7/072049

Issue 7

Volume 1371

The herbaceous Taraxacum officinale, known as dandelion, is found in various regions including America, Europe, Asia, India, and Africa. This particular study aimed to assess the potential of Taraxacum officinale extracts in mitigating the toxic effects of ethylene glycol. There were twenty-five rabbits split up into several groups: a control group without any additives, a group fed ethylene glycol, and several groups fed Taraxacum officinale extracts containing compounds such as flavonoids, glycosides, and alkaloids (at a dosage of 50 mg/kg body weight) once daily for 60 days. Blood samples were collected using plain and EDTA tubes for clinical examination. The results revealed significant elevations (P=0.05) in AST, ALT, ALP, urea, creatinine, globulin, and monocytes in the group fed ethylene glycol (group II). Conversely, there were notable decreases (P=0.05) in protein, albumin. However, after the administration of Taraxacum officinale extracts. ALT, on the other hand, did not show a significant decrease. Additionally, there were significant increases (P=0.05) in protein, A/G ratio, and blood pressure. © Published under licence by IOP Publishing Ltd.

Read Publication

Insights into Male Infertility: A Clinical Examination of Hormonal and Adipokine Profiles in Mosul

Nov 28, 2023

Journal Journal of Wildlife and Biodiversity

publisher Institute of PDepartment of Environmental Sciences, Arak Universityhysics

DOI 10.5281/zenodo.10251849

Issue Special Issue

Volume 7

Infertility is a global concern affecting numerous couples, with hormonal imbalances and adipokines contributing to approximately half of all cases. This study explores the impact of male hormones and adipokines on infertility, measuring various parameters in the blood serum of men with and without identified reasons for infertility, as well as fertile men. Findings reveal a significant decrease in testosterone and an increase in FSH, LH, PRL, and E2 in infertile men compared to the control group. While RETN and Visfatin showed no significant differences, CHEM exhibited variations among infertile and control groups. The study establishes positive connections between certain hormones and age, smoking, and periods of infertility. Identifying these variables could aid in diagnosing and treating infertility. © 2023, Department of Environmental Sciences, Arak University. All rights reserved.

Read Publication

GREEN BIOSYNTHESIS OF SILVER NANOPARTICLES FROM TARAXACUM OFFICINALE ROOTS PLANT AND STUDYING ITS ANTIVIRAL PROPERTIES TO CORONAVIRUS (SARS-COV-2) INFECTED LUNG CELLS

Mar 8, 2023

Journal Journal of Hygienic Engineering and Design

publisher Consulting and Training Center - KEY

Issue Special Issue

Volume 42

Plants, especially medicinal plants, took up the most space during the production of silver nanoparticles and have shown significant promise for use in biotechnology. So the goal of this research was to focus on a type of lung cell line, the WI-38 cell line, infected with the Corona virus. The study also included the isolation of the active compounds from the roots of the Taraxacum officinale plant, their extraction, and the study of their biological effects. Used in this study were: Taraxacum officinale extract, silver nitrate, (Dulbecco’s Modified Eagle Medium (DMEM), fetal bovine serum (FBS) L-glutamine, penicillin, streptomycin, and dimethyl sulfoxide (DMSO) from Sigma Aldrich, USA), and XTT (2,3-bis(2-methoxy-4-nitro-5-sulfo phenyl)-2H-tetrazolium5-carboxamide) from RIbobio-China. WI-38 CCL75 cell lines were purchased from American Type Culture Collection (ATCC) identification. Source was the lung tissue for female-3 month gestation and the SARS-CoV-2 virus. Oils, flavonoids, glycosides, and tannins from Taraxacum officinale were extracted in the extraction device (Soxhlet) in successive stages using several solvents. Silver nanoparticles Ag NPs were synthesized using the green method from these extracts and diagnosed by X-Ray diffraction analysis XRD, Fourier transform infrared spectroscopy (FTIR), and field emission scanning electron microscopy (FESEM). Cell cultures were used to study the effect of nanoparticles on lung cells infected with the Coronavirus (SARS-CoV-2) using lung cell lines (wi-38) . The activity of these particles as antivirals was evaluated due to their antiviral activity where pure cultures of cell lines were planted on DMEM where DEME was used as a positive control and the cell line with DMEM was a negative control. For each experiment, the diameter of the inhibition area was measured in millimeters. Finally, the XTT test was used to test the extracted and the nanoparticle solution to ensure its suitability for inhibition of the virus coronavirus (SARS-COV-2). The results showed that nanoparticles have strong antiviral efficacy against the coronavirus. 50 mg/L of the Ag NPs extract was found to have the greatest inhibition. The potent bioactivity of the synthetic green silver nanoparticles derived from medicinal plants supports their biological use as an antiviral. The study also showed the effects of different concentrations of silver nanoparticle solutions on cell growth. The presence of phenolics and flavonoids was found in the alcoholic and aqueous extracts of the T. officinale roots. The mechanism of action of Ag NPs was investigated. As noted, the Ag NPs alcoholic extract outperformed the Ag NPs aqueous extract in terms of growth because of its small size. From this study, we conclude that the method of green biosynthesis of metal nanoparticles is considered safe and inexpensive, and the materials produced are not contaminated. Nanoparticles can be applied in many applications depending on their physical properties, such as the size and shape of the particle. They were also tested in vitro against coronavirus (SARS-COV-2) utilizing the cell line. Interestingly, the antiviral activities of Ag NPs alcoholic and aqueous extracts against SARS-CoV-2 were noteworthy, with IC50 values of 32.50 and 29.03, respectively. The findings might be a suitable starting point for future optimization and more sophisticated preclinical and clinical research of molecules on single components, particularly alcoholic extract, for inhibiting and lowering the activity of the Coronavirus in infected cells. © 2023, Consulting and Training Center - KEY. All rights reserved.

Read Publication

Synthesis and Biological Activity of few Pyrimidines Derivatives against Hepatic Injury Stimulated by Carbon Tetrachloride in Male Rats

Dec 14, 2022

Journal International Journal of Drug Delivery Technology

publisher Consulting and Training Center - KEY

DOI 10.25258/ijddt.12.4.02

Issue 4

Volume 12

In the presence of sodium hydroxide, substituted chalcones are reacted with cyanoguandine in ethanol, and some chalcone compounds are used as a nucleus in the preparation of some five-, hexa-, and hepta-, heterocyclic compounds pyrimidine (pyrimidines derivatives), pyrimidine derivatives (A1, A2, and A3). Contains therapeutic properties and bioactivity, and has been used to treat various ailments. This study aimed to learn more about how pyrimidine derivatives could help mitigate the undesirable implications of carbon tetrachloride. a group of 50 male rats were separated into 5 groups: healthy control (no treated), CCl4 group, and the rest. A1 (N-(6-(5-methylthiophen-2yl)-4-phenyl-3,4-dihydropyrimidin-(1H)-ylidene) cyanamide), A2 (N-(6-(5-methylthiophen-2yl)-4-(4-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-ylidene)cyanamide), A3 (N-(4-( Melting points, (FTIR) spectroscopy,1HNMR spectroscopy, and thin layer chromatography method (TLC) were used to describe compounds [A1, A2 and A3] to monitor the impacted liver function. Pyrimidines derivatives compounds reduced CCl4 toxicity while increasing the levels of aspartate transaminase, alanine transaminase, gamma-glutamyltransferase, and alkaline phosphatase, unlike the CCl4 group and the CCl4 groups containing pyrimidines derivatives. The quantities of total lipids, protein, globulin, and albumin in the control group were substantially different (P0.05). Lipid peroxidation produced a considerable quantity of malondialdehyde compared to the control group, the CCl4 group. However, pyrimidines derivatives components reduced the quantity CCl4, lowering oxidative stress. The levels of catalase, glutathione, and glutathione peroxidase were higher in individuals who were given just CCl4 elevated in groups of pyrimidines derivatives component. There were substantial disparities in superoxide dismutase levels throughout the groups studied. © 2022, Dr. Yashwant Research Labs Pvt. Ltd.. All rights reserved.

Read Publication

Purification, Characterization, and Inhibition of Tyrosinase from Jerusalem Artichoke (Helianthus Tuberosus L.) Tuber

Oct 12, 2021

Journal Reports of Biochemistry and Molecular Biology

publisher ConnVarastegan Institute for Medical Sciencesect Journal

DOI 10.52547/rbmb.10.3.495

Issue 3

Volume 10

Background: Because it tends to cause deterioration in the quality of food and appearance, food browning is unacceptable. Tyrosinase, which catalyzes the transformation of mono phenolic compounds into o-quinones, has been associated with this phenomenon. Natural anti-browning agents were used to help avoid the enzymatic browning that occurs in many foods. Methods: Tyrosinase of Jerusalem Artichoke tubers was purified through (NH4)2SO4 sedimentation, dialysis, chromatography, and finally gel electrophoresis. The purified enzyme was characterized and inhibited by rosemary extracts. Results: Purification of tyrosinase from Jerusalem Artichoke tuber were accomplished. The specific activity at the final step of purification increased to 14115.76 U/mg protein with purification fold 32.89 using CM-Cellulose chromatography. The molecular mass was evaluated by electrophoresis and found to be 62 KDa. Maximum tyrosinase activity was found at 30 °C, pH 7.2, and higher affinity towards L-tyrosine. Inhibition percentage of heated extracts for leaves and flowers on tyrosinase activity was better than nonheated with 29.65% and 23.75%, respectively. The kinetic analysis exposed uncompetitive inhibition by leaves and flowers heated extracts. Conclusions: In this study, we concluded the usage of natural anti-browning inhibitors like rosemary extract be able to be castoff to substitute the chemical agents which might be dangerous to social healthiness. Natural anti-browning agents can be used to prevent the browning of many foods. © 2021. All Rights Reserved.

Read Publication

PROTECTIVE EFFECT OF MELILOTUS INDICUS L AGAINST HEPATIC INJURY STIMULATED BY CARBON TETRACHLORIDE IN MALE RABBITS

Oct 2, 2021

Journal https://www.scopus.com/record/display.uri?eid=2-s2.0-85135980716&origin=recordpage#

publisher Connect Journal

Issue 2

Volume 21

Melilotus indicus L. is an attractive plant for its medical applications, which is found in tropical regions. The current study tends to assess the potential of Melilotus plant for reducing the toxicity of CCl4 compound. Thirty male rabbits were placed into five groups, i.e., control group, group fed with CCl4 and the remain of groups were fed with Melilotus compounds (alkaloids, flavonoid and glycoside) to detect its effect on liver efficiency. Lipid peroxidation revealed increasing levels of malondialdehyde in the CCl4 group in comparison to the control group, however, Melilotus compounds decreased the level of CCl4, which in turn reduced the oxidative destruction. Catalase, glutathione and glutathione peroxidase levels recorded high levels in the groups fed with Melilotus compounds in comparison with those fed only with CCl4. Superoxide dismutase levels were about the same in all studied groups. There was a significant difference (P > 0.05) in CAT and MDA values across both groups, however, no significant difference (P < 0.05) was observed in other parameters such as GSH, GPx and SOD. CCl4 increased the levels of alanine transaminase, aspartate transaminase, alkaline phosphatase and gamma glutamyltransferase, while Melilotus compounds reduced the toxic effect of CCl4. In contrast to the CCl4 group and the CCl4 groups fed with Melilotus plant compounds, there was a significant difference (P > 0.05) in albumin, total protein, globulin values and A/G ratio in the control group. © 2021. All Rights Reserved.

Read Publication

The protective effect of annona extracts on renal histopathology induced by ethylene glycol in male rabbits

Dec 23, 2020

Journal Indian Journal of Forensic Medicine and Toxicology

publisher Institute of Medico-Legal Publications

DOI 10.37506/ijfmt.v14i4.12121

Issue 4

Volume 14

Annona is one of the many plant extracts that have been explored owing to their anti-inflammatory and anticancer effects. Male locale rabbit were separated into five groups, Group I consider as control, The 4th other groups were treated orally with 0.75% ethylene glycol (EG) to induce renal damage this treatment done till 30th days. Group III to V animals were served as curative regimen and received flavonoids, glycosides and alkaloids extract of the plant of Annona at a dose of 100 mg/kg body weight from 15th day to 30th day. The extracts was administered twice daily by oral route. significant kidney injury in EG animals as demonstrated by a significant elevation (P= 0.05) in serum activities urea, creatinine, total protein and calculated globulin levels. Meanwhile there was significant drop (P=0.05) in albumin, and A/G ratio compared to the control and treated group, The levels of lipid peroxidation were significantly higher in the Serum of the groups of animals treated with EG, while the levels of SOD, CAT and GPx were significantly lower than animals were treatment of EG group with Annona significantly elevated the antioxidant mechanisms differ with that before treatment. Renal Histopathological changes includes deposition of oxalates in the renal tubules lumen, degeneration and necrosis of epithelium of renal tubules, congestion of blood cells, infiltration of inflammatory cells and atrophy in glomerular tuft leading to expansion of bowmans spaces. While Histopathological changes in animals group treated with Annona extract and ethylene glycol were limited dilatation of renal tubules with vascular changes with blood vessels congestion and interstitial hemorrhage, reduced renal damage revealed by less degenerative and necrotic lesion in tubular epithelium and no inflammatory reaction and the glomeruli appeared normal compared with ethylene glycol sections. © 2020, Institute of Medico-Legal Publications. All rights reserved.

Read Publication

Evaluating the potential of annona muricata L. plant compounds as reducing agents for toxicity of ethylene glycol

May 12, 2020

Journal Annals of Tropical Medicine and Public Health

publisher Ahro Scientific Publishing

DOI 10.36295/ASRO.2020.23931

Issue 9

Volume 23

Annona muricata L. is a tropical plant, which is considered as an attractive species due to its medical uses and bioactivity. This study evaluated the potential of Annonaplant for decreasing the toxic effect of ethylene glycol. Twenty five male rabbits were divided into five groups, i.e., control group (without any additives), group fed with ethylene glycol and the rest of groups were fed withAnnona muricata L. compounds (flavonoid, glycoside and alkaloids) to monitor its impact on liver activity. Results revealed that ethylene glycol increased the levels of aspartate transaminase, alanine transaminase, gamma-glutamyltransferase and alkaline phosphatase, whereas Annona compounds decreased the toxicity of ethylene glycol.A significant difference (P< 0.05) in total protein, albumin, globulin values as well as A/G ratio was observed in the control group in comparison to ethylene glycol group and ethylene glycol groups with Annona muricata L. plant compounds. Lipid peroxidation resulted in high level of malondialdehyde in the ethylene glycol group in comparison to the control group, however, Annona compounds reduced the level of ethylene glycol, which in turn decreased the oxidative damage. Glutathione, catalase as well as glutathione peroxidase levels increased among the groups fed with Annona compounds in comparison to that fed with ethylene glycol only. Superoxide dismutase recorded approximately the same levels in all tested groups.There was a significant difference (P< 0.05) in MDA and CAT values in all groups, while no significant difference (P> 0.05) was observed in other parameters, i.e., GSH, GPx as well as SOD levels. © 2020 Wolters Kluwer Medknow Publications. All rights reserved.

Read Publication

Alterations in antioxidants and trace element with interleukin 6 level in β thalassemia major patients

Mar 22, 2020

Journal Medico-Legal Update

publisher World Informations Syndicate

DOI 10.37506/v20/i1/2020/mlu/194500

Issue 1

Volume 20

β- Thalassemia major is an inherited blood disorder caused by drop or total absence of beta globin chains. Patients with this blood disorder are repeatedly needed to blood transfusion to survive. There are many experimental and clinical evidence that suggested that the oxidative stress and free radical plays an important role in thalassemia. The aim of the present study was to investigate the level of antioxidant enzymes and trace element with interleukin 6 in β thalassemia major patients. The blood samples were obtained from 50 patients (30 with β-thalassemia major and 20 healthy controls).The serum levels of MDA, GSH, Vitamin (E, C), trace element (Fe, Zn, Cu, Se) and antioxidant enzymes (SOD, CAT, GPx) and interleukin 6 were anaslysed using conventional methods. The results showed that the level of MDA, Fe, Cu and interleukin 6 were significantly increased (P<0.05), whereas the activities of GSH, Vitamin (E, C), trace element (Zn, Se) and antioxidant enzymes (CAT, GPx) were decreased significantly (P<0.05) in β-thalassemia major patients compared with healthy control. This results suggested that the β thalassemia patients disease activity `and progress could be investigated by determining the oxidative stress marker, trace element and interleukin 6 levels. © 2020, World Informations Syndicate. All rights reserved.

Read Publication

Antiurolithiatic activity of the plant extracts ofannonaon ethylene glycol induced urolithiasis in rabbits

Dec 21, 2019

Journal Indian Journal of Forensic Medicine and Toxicology

publisher Indian Journal of Forensic Medicine and Toxicology

DOI 10.5958/0973-9130.2019.00493.6

Issue 4

Volume 13

Ethylene glycol (EG)is a colorless, odorless, sweet-tasting chemical mainly used as antifreeze which is fatal if ingested. Annonais used as spices and as an herbal medicine (antioxidant) in America countries. Aim of the research was to evaluate the protective role of annonaceae against the Ethylene glycol as toxicity in rabbits. Twenty fiverabbits were divided into five groups: (GI,control group) 5rabbitsuntreated with Ethylene glycol and(GII) 5rabbits were give 0.75% Ethylene glycol in drinking water onlyfor 30 days, while (GIII, GIV and GV)15 rabbits were give 0.75% Ethylene glycol in drinking water and oral supplementation of Annona (flavonoids, glycosides and alkaloids) extracts(100mg /kg Bw) two times daily for 30 days.Blood samples were collected (plain tube & EDTA tube) to clinicalexamination. EG induced significant reduction (20%) in rabbits BW in G II in comparison with GI, GIII, GIV and GV.The result show, AST, ALT, ALKP, TBIL, MDA, SOD,urea,creatinine,globulin andmonocytesin G II were significantly elevated (P=0.05); meanwhile there were significant decrease (P=0.05) in total protein, albumin, A/G ratio, Gpx, CAT, GSH, BP, Hb,WBC and RBC. But after treatment by extracts of Annonasignificant reduction inAST, ALKP, TBIL, MDA,urea,creatinineandmonocytes, while SOD,ALTno significant decrease. Meanwhile there were significant increase (P=0.05) in total protein, A/G ratio, Gpx, GSH, BP, Hb, WBC and RBC. © 2019, Indian Journal of Forensic Medicine and Toxicology. All rights reserved.

Read Publication