Synthesis of some heterocyclic compounds derived from furfural using ultrasonic waves

Sep 28, 2019

Journal Journal of Scientific & Technical research

publisher Mohammad S Al-Ajely

DOI 10.26717/BJSTR.2019.22.0036

Issue 1

Volume 22

Introduction Furfural was first time produced industrially from rice huks in1840 after drying mixing with sodium chloride and addition of 10% H2SO4 and distilled water [1], Other researchers have synthesized it from rice straw in 2007 [2]. Punsuvon and his coworkers have synthesized furfural from sugar cane stalks and sulfuric acid [3] with an overall yield of 71%. In 2010 researchers have succeeded to synthesize furfural from xylose sugar [4]. In 2012 other researchers have prepared furfural from epic rap of wild mango [5]. In 2016 researchers have prepared furfural from bagasse [6] According to the above works it was known that furfural is cheap precursor and was used for the synthesis of variety of heterocyclic compounds. Furfural itself and its derivatives MCA, MBA for example 4, 5-Dibromofurfuraldehydle, 2-(2-furyl)[1, 3] dioxane, 5-nito (1, 3-imidazolyl-2, 5-dion)-3-yl furfuraldine was used as drag in treatment of urinary tract [7, 8]. Among the reactions of furfural are the synthesis of tetrazine derivatives [9], furyl methylene diacetate [10] and 4-methyl furfural [11]. Among the known reactions of furfural which leads to the formation of heterocyclic compounds are the synthesis of 1, 3-imidizolyl-2, 5-furfuryl amine-2, s5-dione which is used for treatment of urinary tract infections [12]. Furoin compound on oxidation forms furil which is known as insect side [13]. flavon compound contains furfural ring, furfuraldehyde exhibited ICso values of 75.9, 51.0 and 59.3 M for HT29, MCF7 and A498 respectively as anti-cancer cell lines [14]. It was also known that bromo derivative of furfural (MBA) reacts with boronyl indole to form indolyl derivatives of furfural, which is

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Synthesis of some diazine and triazole derivatives from furfural‏

Apr 7, 2019

Journal International Journal of Research

publisher Mohammad S Al-Ajely

DOI 10.5281/zenodo.2653118

Issue 4

Volume 7

The synthesis of heterocyclic compounds especially when their structure containing nitrogen, oxygen and sulfur atoms are growing up due to their wide spread in nature, many mechanistic pathways to reach the target with nearly negligible loss of their dose and there are numerous me thods to derivatives their structures There for the development in hetero cyclic synthesis will provide new metabolic pathways when these compounds have succeeded to be used as drug, Moreover it was known for long time that about 95% of cancer drugs are heterocyclic compounds. There are also many methods found in the literature for the synthesis of both triazoles and trdiazines from different routes In this investigation furfural was used as precursor for the synthesis of some new diazine and triazole derivatives (3-11). The synthesized compounds were characterized by IR, and 1HNMR and are discussed

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Synthesis of Some Piperidine, Pyrmidine and Diazipine Compounds Containing Furyl Derivatives

Apr 2, 2019

Journal Archives of Nanomedicine: Open Access Journa

publisher Mohammad S Al-Ajely

DOI 10.32474/ANOAJ.2019.01.000125

Issue 5

Volume 1

It was known that nearly 65% of anti-cancer drugs granted market approved by FDA between 210-1015 are heterocyclic compounds and about 95% of heterocyclic compounds are drugs. Heterocyclic compounds containing nitrogen atoms in their structures (nitrogen based) were also proved by FDA during the above period that they form two third of cancer drugs. There are many corresponding reviews associated with the impact and usage of different heterocyclic compounds as anti-platelet, antihypertensions and a lot of biological and medicinal applications. So according to the importance of heterocyclic compounds in therapeutic and a variety of pharmaceutical, medicinal applications which attracts attentions of many researchers on synthesizing new compounds of this class. We are here synthesizing some new nitrogen containing heterocyclic compounds, Piperidine compounds (E4-8), 1, 4-Dihydropyridine derivatives (E9-20) And finally diazepine compounds (E31-37) The synthesized compounds were studied using IR and1H NMR Spectral methods and were discussed

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Synthesis of Some Piperidine, Pyrmidine and Diazipine Compounds Containing Furyl Derivatives

Apr 2, 2019

Journal Archives of Nanomedicine: Open Access Journa

publisher Mohammad S Al-Ajely

DOI 10.32474/ANOAJ.2019.01.000125

Issue 5

Volume 1

It was known that nearly 65% of anti-cancer drugs granted market approved by FDA between 210-1015 are heterocyclic compounds and about 95% of heterocyclic compounds are drugs. Heterocyclic compounds containing nitrogen atoms in their structures (nitrogen based) were also proved by FDA during the above period that they form two third of cancer drugs. There are many corresponding reviews associated with the impact and usage of different heterocyclic compounds as anti-platelet, antihypertensions and a lot of biological and medicinal applications. So according to the importance of heterocyclic compounds in therapeutic and a variety of pharmaceutical, medicinal applications which attracts attentions of many researchers on synthesizing new compounds of this class. We are here synthesizing some new nitrogen containing heterocyclic compounds, Piperidine compounds (E4-8), 1, 4-Dihydropyridine derivatives (E9-20) And finally diazepine compounds (E31-37) The synthesized compounds were studied using IR and1H NMR Spectral methods and were discussed

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Synthesis of Some Heterocyclic Compounds Derived from Furfural‏

May 27, 2018

Journal Journal of Addiction Research

publisher Mohammad S Al-Ajely

Issue 1

Volume 2

We know that most heterocyclic compounds are drugs or co-drugs. In our investigation furfural was used as a precursor for heterocyclic synthesis, either by ring opening of furfural going to pyrimidine derivative E3 then functionalizing this pyrimidine into its derivatives E8, E10 and cyclization into oxadiazole and thiadiazoles E8, 11. Or the reaction of pyrimidine with dimedon derivatives to afford dimedino pyrimidine derivatives. The second pathway involve the synthesis of oxamyl derivative of pyrmidine E21-25 these compounds were cyclized into new oxadiazoles E24-26. The third pathway involve the synthesis of mucobromic esters E27-29 from MBA acid then these esters were converted into the correspondig lactones E30-32 and E32-36 while reacting MBA with amines affording N-alkyland N-amidolactams. The last pathway was the reaction MBA with methanol, sodium azide to give azidointermeddiate which was cyclized with alkene or alkynes into triazole derivatives E42-49. The synthesized compounds were characterized by IR and some 1HNMR measurements

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