Maryam Khadim Taher

Year: 2023

Academic Degree: Master

Supervisor Type: Co-supervisor

Supervisor State: Graduated

Supervisor for the MSc student at Maysan University, College of Sciences, Chemistry Dept.

Ph.D. in Microbiology – Al-Mustansiriya University, Iraq (2022)

Sep 7, 2019 - Feb 3, 2022

Focused on advanced microbiological and immunology research, infectious diseases, and autoimmune diseases.

Master’s in Microbiology

Sep 10, 2009 - Jan 20, 2011

Specialized in the association between Mycoplasma pneumoniae and allergic asthma

Bachelor’s in Microbiology

Oct 2, 2004 - Jul 1, 2008

Specialized in microbiological analysis, laboratory techniques, and disease pathogenesis.

Microbiology and Immunolgy [Assistant Professor Center of Technical Research, Infectious Agents Research Branch]

Nov 17, 2023 - Mar 7, 2024

Conduct academic research in microbiology, immunology, and infectious diseases.

Teach undergraduate and graduate-level courses in microbiology and related fields.

Supervise postgraduate research and thesis work.

central promotion committee [Director of the Central Division of Scientific Promotions]

Mar 7, 2024 - Oct 12, 2024

Oversaw the evaluation and promotion processes for academic staff across the university.

Coordinated with university departments to ensure compliance with academic advancement criteria.

Contributed to streamlining promotion procedures and ensuring transparency and academic standards.

Medical Laboratory Techniques [Assistant Professor – Department of Medical Laboratory Techniques]

Feb 10, 2024 - Present

Teach courses in laboratory techniques and diagnostics to undergraduate students.

Design and implement practical lab sessions in alignment with the course curriculum.

Provide academic advising and mentorship to students pursuing careers in medical technology.

Participate in departmental meetings and curriculum development

Scientific Affairs [Assistant Dean for Scientific Affairs Technical Institute of Mosul, Northern Technical University]

Oct 12, 2024 - Present

Supervise scientific and academic affairs, including research, curriculum development, and postgraduate programs.

Coordinate scientific committees and ensure compliance with academic policies.

Support faculty in research planning, proposal writing, and grant applications.

Enhance institutional research output and academic collaborations

Estimation of antibacterial activity of zinc oxide, titanium dioxide, and silver nanoparticles against multidrug-resistant bacteria isolated from clinical cases in Amara City, Iraq

Aug 19, 2019

Journal Drug Invention Today

Issue 11

Volume 11

Background: Gram-negative bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii are responsible for health-care-associated infections and hospital outbreaks, with multidrug resistance to antimicrobial agents such as aminoglycosides, carbapenems, cephalosporins, fluoroquinolones, and polymyxins. It is found that the frequent use of antibiotics has led to the emergence of nearly all antibiotic super bacteria which carry the super-resistance gene called NDM. Materials and Methods: Three species P. aeruginosa, A. baumannii, and Serratia marcescens isolated from clinical cases, their diagnosis and antibiotic susceptibility testing were achieved using Vitek2 systems depending on Gram-negative diagnosis and sensitivity cards. Results: The results revealed that P. aeruginosa and A. baumannii were resistant to antibiotics (ticarcillin, piperacillin, piperacillin/tazobactam, ceftazidime, aztreonam, imipenem, meropenem, gentamicin, tobramycin, ciprofloxacin, minocycline, and trimethoprim/sulfamethoxazole) used in this study, oppositely, S. marcescens was sensitive. The results also showed that minimum inhibitory concentration (MIC) of nanoparticles (NPs) is varying according to the type of NPs, the dimension, and bacterial species; the MIC for zinc oxide (Zn O) NP sizes (20, 30, 50, and ~ 150 nm) was determined between 625 and 2500 µg/ml, titanium dioxide (TiO2 ) NP sizes (10, 50, and 100 nm) were 3125–50,000 µg/ml, and silver NPs (AgNPs) (90 nm) were 2500 µg/ml for all isolates. In addition, our results reported that S. marcescens isolate was resistant to TiO2 (10 nm) NPs. Conclusion: ZnO NPs found to have best activity against bacterial growth compared to AgNPs and TiO2 NPs, suggesting the use of these NPs in special preparation to treat such multidrug-resistant bacteria.

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Prevalence of Helicobacter pylori infection in diabetic and nondiabetic patients

Oct 1, 2019

Journal Drug Invention Today

Issue 10

Volume 11

Background: Recently, new evidence began to emerge indicating a relationship between diabetes and Helicobacter pylori infections. Materials and Methods: For this purpose, a random sample of 140 (76 male and 64 female) subjects. They were divided into two main groups, diabetic and nondiabetic patients. H. pylori was detected in 71 (50.7%) of samples while 69 (49.3%) of samples were H. pylori negative. Results: Out of 71 patients positive for H. pylori, 40 (57%) were not diabetic, while 31 (43%) were diabetic, as the glucose concentrations in the blood increased significantly in compare with bacteria infected nondiabetic patients. In correlation with age, the present study showed that the rates of infection vary according to the age groups. The current study found that H. pylori infection was higher in males than in females, and in the center of Maysan Governorate (urban) rather than the districts and areas (rural). Conclusions: The study concluded that H. pylori bacteria significantly increased blood sugar concentration in nondiabetic individuals, making them more susceptible to future diabetes unless treated

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Tamoxifen from chemotherapy to antiviral drug: Possible activity against COVID-19

Apr 7, 2020

Journal Biomedical and Biotechnology Research Journal

publisher Wolters Kluwer

DOI 10.4103/bbrj.bbrj_53_20

Issue 4

Volume 2

Tamoxifen (TAM) is the oldest and the most-prescribed selective estrogen receptor modulator (SERM). It is a member of the triphenylethylene group. TAM has been used to treat breast cancer that spreads to other parts of the human body; it is also utilized to decreasing the chances of breast cancer developing in high-risk patients. Recently, some studies focused on the potential antimicrobial action of TAM. Coronaviruses are enveloped positive-sense RNA nucleic acid viruses that have club-like spikes, characterized by a distinctive replication strategy; they are round and sometimes pleomorphic in shape. Coronavirus disease 2019 (COVID-19) is regarding the new genera of coronaviredia that appeared for the first time in Wuhan, China, in early December 2019. Due to the continuous spread of the novel COVID-19 with the exponential rise in death numbers, new therapeutic development is urgent; in general, there are no specific antiviral drugs or vaccines for 2019-nCoV. Hence, this review will discuss the most recent information about the antiviral action of TAM against COVID-19 infection by trying to give a deep understanding of major properties, mechanisms of action, immune system responses, and antimicrobial efficiency of TAM that is regarding the promising way to treat COVID-19 novel infection. The current review may serve as an impetus for researchers working in the field of medical microbiology, vaccination, and antiviral drug design. The review also rationally reports and critically analyzes the available knowledge by focusing and mentioning future steps and strategies trying to find appropriate solutions regarding challenges in COVID-19 management by TAM utilization.

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Allergic rhinitis caused by foods and their correlation to certain food allergens.

Aug 1, 2020

Journal EurAsian Journal of Biosciences

publisher EurAsian Journal of Biosciences

Issue 2

Volume 14

Allergic rhinitis is an important health concern that affects the life quality and economy of different societies. Few studies were conducted to find the effects of different foods on the development of allergic rhinitis, hence, the current study aimed to diagnose allergic rhinitis caused by foods and figure out the correlation between foods and allergic rhinitis. 200 people with nasal symptoms suspected to be due to allergic reaction were included and subjected to the skin prick test using standard food and inhalant allergens solutions. The results found that 46% of allergic rhinitis cases are caused by foods. The most frequent food allergen associated with the development of allergic rhinitis is cumin (88.98%). Other foodstuffs in descending order are tea (62.96%), pepper (59.25%), almond (51.85%), coffee and carrot (44.45%) banana casein, cow milk and egg (37.03%), apple (33.34), chicken and olive (29.62%), celery and peach (25.92), and finally, the apricot with percent reached to (22.23%). Pearson correlation test revealed that a significant relationship is found between cumin, tea, olive, almond, carrot, and cow milk. The present study concluded that food allergens are responsible for the occurring of 46% of allergic rhinitis cases. Allergic rhinitis was appeared to significantly associate with cumin, tea, olive, almond, carrot, and cow milk in all cases tests positive for food skin prick test.

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Incidence of hepatitis C infection among multi-transfused β-thalassemia major patients and its correlation to blood groups in Amara City

Sep 9, 2020

Journal IMDC-SDSP 2020: Proceedings of the 1st International Multi-Disciplinary Conference Theme: Sustainable Development and Smart Planning, IMDC-SDSP 2020, Cyperspace, 28-30 June 202

publisher EAI

Issue 44

Volume 65

Multi-transfused β- thalassemia major patients still at high risk of acquiring blood-borne viruses just like hepatitis C (HCV), hepatitis B (HBV) and human immunodeficiency virus (HIV). To estimate the percent of HCV infection among multi-transfused β- thalassemia major patients, a sample of (109) β- thalassemia major patients were subjected to anti-HCV screening test using enzyme-linked fluorescent assay (ELFA) technique. The results revealed that 30 (27.5%) patients present + anti-HCV in Amara city. However, the infection rate was higher in the male gender than females and increased with age. The results also found that HCV infection is predominant in B+, O+, and A+ blood groups, moreover, a highly significant positive correlation detected between HCV infection and B+ blood group . The study concluded that there is an elevated rate of HCV infection among β- thalassemia major patients, requiring more efficient viral screening techniques to the blood donors, the positive relationship between blood group and HCV infection suggests a role of gene-environment interaction and needing molecular studies to clarify such correlation.

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Evolution of some Biochemical and Hematological Parameters of Thalassemia Patients in Maysan Governorate, Iraq

Oct 1, 2020

Journal Annals of Tropical Medicine & Public Health

DOI http://doi.org/10.36295/ASRO.2020.231238

Issue 12

Volume 23

Abstract: Thalassemia is inherited anemia publicity that common in the world and especially in Mediterranean region, and the most important cause of mortality in patients. The study included (108) patients (males & females) with thalassemia in Amara city and (20) healthy individuals as a control group. All subjected to examination tests for assessment hematological parameters as well as liver functions tests.The results showedasignificant increase(p<0.01) in glutamic pyruvic transaminase (GPT), glutamic oxaloacetic transaminase (GOT),andAlkaline Phosphatase (ALP) in patients with thalassemia compared with healthy subjects, however, total bilirubin concentration(TSB) did not show significant difference.There are also a significant increases (p <0.01) in White blood cells (WBC) and Platelets (PLT), While Red blood distribution width (RDW) in thalassemia patients compared with healthy subjects,Red blood cell (RBC), Mean cell volume (MCV), Mean corpuscular hemoglobin (MCH), Mean concentration of hemoglobin (MCHC),Hemoglobin (Hb) showed significant decrease (P <0.01) in thalassemia patients compared with healthy subjects. In conclusion: liver enzymes GPT, GOT, and ALP were significantly higher in thalassemia patients, hematological parameters were contradictive when compared with healthy subjects.

Potential antiviral properties of antifungal drugs

Oct 19, 2020

Journal Journal of the Egyptian Women's Dermatologic Society

DOI 10.4103/JEWD.JEWD_40_20

Issue 3

Volume 17

The widespread therapeutic use of antifungal drugs has given rise to multiple interests, and their research and development have become quite rapid, emerging as an active highlight topic [1]. It has been proposed that the efficacy of some antifungal agents may be related to their capacity to induce human cytokine production. This was confirmed when fluconazole was reported to increase CCL3 and CCL4 level in the supernatants of human mononuclear cell cultures [2]. Itraconazole (ITZ) and posaconazole (POS) belong to triazoles that are broad-spectrum antifungal agents, commonly used to prevent and treat several lung fungal infections and other medically significant fungi that cause superficial, subcutaneous, and systemic infections in humans [3]. The mechanisms action of these drugs is by interacting with cytochrome P450 enzymes, via inhibition of particular lanosterol 14α-demethylase, which is important for biosynthesis in fungal membrane function and growth [4].

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Serum Levels of Interleukin-6, Ferritin, C-Reactive Protein, Lactate Dehydrogenase, D-Dimer, and Count of Lymphocytes and Neutrophils in COVID-19 Patients Its Correlation to the Disease Severity

Mar 7, 2021

Journal Biomedical and Biotechnology Research Journal

publisher Wolters Kluwer

DOI 10.4103/bbrj.bbrj_188_20

Issue 5

Volume 1

Background: Since its first emergence in Wuhan city, China, severe acute respiratory syndrome coronavirus 2, which is responsible for the pandemic COVID-19, has become a significant health problem all over the world affecting over 2.1 million people globally. Methods: The current study aimed to investigate serum levels of interleukin 6 (IL-6), ferritin, C-reactive protein (CRP), lactate dehydrogenase (LDH), D-dimer as well as lymphocytes and neutrophils count in COVID-19 patients and to clarify the correlation of these parameters with disease severity and progression. For these purposes, (100) patients with COVID-19 (confirmed by polymerase chain reaction) and (20) apparently healthy people (with matched age and sex) were included in the current study and considered as a control group.Results: All study population (patients and control) were subjected to the evaluation of serum levels of IL-6, ferritin, CRP, LDH, D-dimer, as well as lymphocytes and neutrophils, count. COVID-19 patients showed a significant elevation in the levels of all parameters included in this study when compared with healthy controls. We also found that all of IL-6, ferritin, CRP, LDH, D-dimer are significantly associated with the severity of the COVID-19 symptoms. Conclusion: Lymphopenia and increased neutrophils were also effectively correlated with disease progression. In line with these results, we concluded a proportional correlation between the aforementioned parameters and COVID-19 suggesting the uses of these tests to the diagnosis of critical cases.

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Correlation between Helicobacter pylori infection and COVID-19

Sep 10, 2021

Journal Iranian Journal of War and Public Health

Issue 4

Volume 13

Aims: COVID-19 and Helicobacter pylori are pathogens associated with the most common viral and bacterial infections globally. The coinfection of pathogenic bacteria and COVID-19 represented a true health challenge. The current study aimed to estimate the incidence of H. pylori in patients with COVID-19. Materials & Methods: This experimental study was conducted in Karbalaa's COVID-19 Isolation Center from Feb. 2021 to July 2021, 130 COVID-19 patients were entered the study. A control group of 130 seemingly healthy people of similar ages and sexes was also enlisted in this research. COVID-19-infected patients were confirmed by Reverse Transcription-Polymerase Chain Reaction device. The samples were processed for total WBCs, and neutrophils were automatically computed. Data were analyzed using SPSS 21 software by independent T and Chi-square tests. Findings: COVID-19 infection was more frequent in males than females, especially between 15 and 25 years. The COVID-19 patients were detected to have increased neutrophils count (p<0.0001) and decreased lymphocytes compared to the healthy persons (p<0.0001). A significant correlation between H. pylori and COVID-19 was discovered, especially in females. Conclusion: H. pylori-infected patients are more susceptible to COVID-19 than other persons without H. pylori infections.

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Identification, Epidemiology and Seasonal Variation of Neisseria meningitidis in Al-Nasiriya City, South of Iraq

Oct 1, 2021

Journal CURRENT APPLIED SCIENCE AND TECHNOLOGY

DOI https://doi.org/10.55003/cast.2022.03.22.015

Issue 3

Volume 22

The study involved 219 meningitis patients registered at AL-Hussein Teaching Hospital over a two-year period to determine the prevalence of Neisseria meningitidis in AL-Nasiriya city and the impact of sociodemographic parameters on infection (from the beginning of 2015 to the end of 2016). A technician extracted cerebrospinal fluid samples from the research population, and then transferred them directly to the laboratory for the identification of bacterial pathogens. The findings revealed that 57 patients (26.02%) were afflicted with Neisseria meningitidis. Twenty-nine cases (50.87%) were in 2015 and 28 cases (49.13%) were in 2016. Our studies showed that the incidence of Neisseria meningitidis was slightly higher in males than in females and in the age group of 20-44 years old. Over the study period, seasonal variation was also shown. This study concluded that meningococcal meningitis infection was affected by sociodemographic influences, which appeared to be prevalent in the long warm seasons of Iraqi weather, with summer having the highest percentage of N. meningitidis infections, followed by fall.

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The Relationship between ABO and Rhesus Blood Groups with Toxoplasmosis in Thi-Qar Province, Iraq.

Dec 1, 2021

Journal Journal of Chemical Health Risks

DOI 10.22034/jchr.2021.1916672.1227

Issue 4

Volume 11

Toxoplasma gondii infects people via the gastrointestinal tract (GIT) that stimulates humoral and cellular immune responses with specific antibodies. Within this same system, the presence of ABO blood group glycoconjugates also arises and can affect human sensitivity to T. gondii infection. During this paper, the frequency distribution of ABO, as well as Rh blood groups in different phenotypes were evaluated to investigate potential relationships with toxoplasmosis and to estimate the incidence of toxoplasmosis among pregnant women in AlNasiriya city. Data-including serology test results for toxoplasmosis and ABO phenotypes of blood groups in women attending Bint-AL Huda and AL-Shatra Hospital in Nasiriya city were collected from starting of (2013) until the end of (2014). It's have been analyzed using version 20 of SPSS. Results of 2861 participating women indicate high prevalence of toxoplasmosis are 1018 (35.6%), 767 (26.8%), 694 (24.3%) and 382 (13.4%) for"B, A, O, and AB"groups respectively. A large portion of them was Rh+ (70.33%). In conclusion, this research was a significant relationship between blood groups, Rh factor and toxoplasmosis. Toxoplasma was relatively high among women in Al-Nasiriya city and Rhesus positive factor, and Blood type B individuals were most affected.

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Incidence of Hashimoto's thyroiditis and its relationship to age, sex, smoking and blood groups.

May 31, 2022

Journal NTU journal of pure sciences

publisher NTU

DOI https://doi.org/10.56286/ntujps.v1i2.175

Issue 2

Volume 1

This study was aimed to demonstrate the incidence of Hashimoto's disease in Iraqi patients and its correlation to some of the sociodemographic features. The research groups involved (50 patients with Hashimoto?s disease and 50 healthy subjects). All of them were subjected to the estimation of levels of free triiodothyronine (FT3), free thyroxine (FT4), TSH, anti-thyroid peroxidase (anti-TPO), and anti-thyroglobulin (anti-Tg). The results demonstrated that there is a dramatic increase in the occurrence of HT in older patients. The age group (41-50 years old) was the most age group affected by Hashimoto's disease, followed by the age groups (31-40, 21-30, and 9-20 years old) respectively. A significant proportional correlation (R:0.952, P:0.024) was found between HT disease and aging. According to the gender, the results found that the vast majority (82%) of patients were females (P = 0.01). Also, the smoking percent was (40%) of patients. The presence of autoimmune thyroid disease in one or more individuals within the family (family history) was also evaluated and the results found that (28%) of the Hashimoto?s disease group have a positive family history of thyroid autoimmune diseases. It can be concluded from these results that females are more prone to developing Hashimoto?s disease compared to males, in other words, the female gender is a risk factor for the occurrence of autoimmune hypothyroidism. Also, the negative impact of smoking and family history gives an indication that these parameters are independent and don’t associate with Hashimoto?s disease at least in the current study.

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Incidence of Helicobacter pylori infection among Hashimoto's Thyroiditis patients in Amara City, Iraq

Dec 1, 2022

Journal Jordan Journal of Biological Sciences

DOI https://doi.org/10.54319/jjbs/150401

Issue 4

Volume 15

The association of different infections with the subsequent occurrence of autoimmunity, just like autoimmune thyroiditis, has recently been increased globally. This study aimed to determine the role of Helicobacter pylori (HP) infection in Hashimoto's disease. The research groups involved 50 patients with Hashimoto’s disease and 50 healthy subjects. All of them were subjected to the estimation of concentrations of free triiodothyronine (FT3), free thyroxine (FT4), TSH, antithyroid peroxidase (anti-TPO), and anti-thyroglobulin (anti-Tg). In addition, for the diagnosis of HP, IgG, as well as antiCagA antibodies in the serum, were detected. An independent t-test was used to test the significance of the means. Also, an odd ratio was used to clarify the association between H. pylori infection and HT disease. Statistical significance was detected when P-value is equal to or less than 0.05. The results indicated that 94% of Hashimoto’s patients and 34% of the healthy subjects were seropositive for HP IgG. Also, (74%) of the HT patients were seropositive for HP IgG/anti-CagA. These results were significant at the level of 0.01 (p< 0.001). Hashimoto’s patients with HP/CagA positive tests have significantly elevated concentrations of anti-TPO (480.69±311.29), anti-Tg (336.00±175.95), and TSH (20.43±18.98) compared with patients tested negatively to HP/CagA antibodies (358.60±281.55, 258.36±170.09 and 9.02±5.94 respectively). In conclusion, there is a relationship between H. pylori infection and the development of Hashimotoʼs thyroiditis in Iraqi patients. H. pylori infection, especially CagA expressing strains, could be a risk factor for the development of autoimmune hypothyroidism and to a lesser extent its progression by increasing the concentration of thyroid antibodies and TSH, which in turn leads to decreased levels of the thyroid hormones and worsening of the disease, requesting antibiotic therapy to eradicate the bacterial infection.

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Asymptomatic individuals with coronavirus disease-19 as infectious cases and encouragement immunity hypothesis

Apr 1, 2023

Journal Journal of Preventive, Diagnostic and Treatment Strategies in Medicine

publisher Wolters Kluwer

DOI 10.4103/jpdtsm.jpdtsm_5_23

Issue 2

Volume 2

Asymptomatic individuals with coronavirus disease-19 (COVID-19) play a significant role in viral transmission. These individuals are in the incubation period as healthy. Until now, the immune responses of asymptomatic individuals have not been fully understood, and research evidence is very lacking but few studies have indicated increases in the number of lymphocytes in the blood, giving them strong cellular immunity. The blood of survivor's silent carriers (asymptomatic individuals) may be used as prophylaxis or/and treatment for patients. This review is focused on COVID-19 transmission, appropriate screening and testing, perspectives on immune responses in silent patients and their role in the transmission of infection, the association of human leukocyte antigen haplotypes and COVID-19 infection, and the perspectives on convalescence plasma and encouragement immunity hypothesis as treatment and/or prophylaxis for COVID-19 management. The current review can serve as an incentive for researchers in the field of immunology, ecology, and virology. The review also rationally reports and critically analyzes the information available by focusing on and identifying future steps and strategies aimed at finding suitable solutions to COVID-19 management challenges by encouraging immunity.

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Evaluate the hematologic parameters, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio in patients with autoimmune hypothyroidism from Amara City, Southern Iraq

Dec 1, 2023

Journal Medical Journal of Babylon

publisher Wolters Kluwer

DOI 10.4103/MJBL.MJBL_369_22

Issue 1

Volume 20

Background: Thyroid diseases are affecting 3%–5% of the women general population. Autoimmune thyroid diseases such as Graves’ disease (GD) and Hashimoto’s disease were detected to be the commonest disorders affecting thyroid function. Objectives: This study is a case–control study that aimed to estimate the effect of HT on hematological parameters. Materials and Methods: A total of 100 persons (50 HT patients and 50 euthyroid groups) of both sexes aged between 15 and 50 years were included in this study during the period April 2021–April 2022. Samples of venous blood (5mL) were obtained from the study participants and used for the estimation of serum thyroid-stimulating hormone (TSH), FT3, and FT4 levels, as well as anti-thyroid peroxidase (TPO), anti-thyroglobulin (TG) concentration, as well as hematologic parameters. Results: The results of this study showed that HT patients had significantly higher levels of TSH as well as thyroid autoantibodies (anti-TPO and anti-TG) and significantly lower levels of FT3 and FT4. A considerable decrease was found in the hematocrit, hemoglobin, and mean corpuscular volume among HT patients, whereas no significant differences were found between the HT patients and the euthyroid group in total red blood cell count, total white blood cell count, neutrophils, lymphocytes, monocytes, basophils, platelet counts, MPV, mean distribution width, plateletcrit, and PLCR. The neutrophil-tolymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) values were significantly higher in the HT patients compared with the euthyroid group. Conclusions: The current study concluded that Hashimoto’s thyroiditis is associated with significant elevation in the serum concentrations of anti-TPO and anti-TG antibodies, high TSH levels, and decreased FT3 and FT4 levels. Hashimoto’s disease resulted in a significant decrease in the hemoglobin concentration; hence, patients with HT could be at risk to have anemia. Also, HT was associated with elevated NLR and PLR values; therefore, NLR and PLR ratios could be used as routine, inexpensive, easily accessible markers at the clinical course or the severity of autoimmune diseases that progress with chronic inflammation.

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Inhibitory Effect of Saccharomyces cerevisiae Against Propionibacterium acnes

Sep 1, 2024

Journal Journal of Bioscience and Applied Research

publisher Society of Pathological Biochemistry and Hematology

DOI https://doi.org/10.21608/jbaar.2024.309074.1061

Issue 3

Volume 10

Acne is an inflammatory disease of the sebaceous glands that results in the formation of papules, pustules, and more advanced complicated scars by opportunistic microorganisms known as Propionibacterium acnes, which feed mainly on fat. This resulted in the development of this acne condition. Reduced use of antibiotics and discovery of medicinal plant treatments because most bacteria become resistant over time. Propionibacterium acnes is a Gram-positive bacterium that plays a major role in the development of some diseases. This study investigated the effect of bread yeast extract against Propionibacterium acnes, which causes acne. The study involved 65 samples collected from 45 patients with acne, 40 of which were comedones and 25 of which were pustules. These samples were collected from adolescent patients at Kirkuk Hospitals (Azadi Teaching Hospital and Kirkuk General Hospital/dermatology outpatient clinics). The patients' ages ranged between (15-30 years old). All 65 purified samples showed P. acne. In this study, we investigated the effects of S. cerevisiae yeast on the growth of P. acne bacteria. A marked effect was observed through the inhibition of the growth of this bacteria, as the diameter of inhibition resulting from the effect of the extract of Saccharomyces cerevisiae ranged from 9.5 mm to 11.5 mm. Based on these results, Can be used the Saccharomyces cerevisiae for acne-related skin treatment.

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