Comparison between Fasting Plasma Glucose and HbA1c in Glycemic Control of Type-2 Diabetic Patients

Dec 12, 2016

Journal Journal of Babylon University/Pure and Applied Sciences

Issue 9

Volume 24

Glycosylated hemoglobin (HbA1c) in diabetic patients reflects the average blood glucose level, and will not be affected by variability in blood glucose in short time. The aim of the study is to compare between fasting plasma glucose and HbA1c in determining the glycemic control and estimate blood pressure, body mass index(BMI),serum cholesterol and triglyceride in type 2 diabetic patients . The study was carried out during the period from 1st July to 31st September 2014 in Kirkuk Azadi teaching Hospital . The study included 75 samples of type 2 diabetic patients their ages 21-71 years old were taken randomly and 40 samples of control subjects.The type 2 diabetes mellitus were diagnosed based on the family history and clinical examination of the patient . 4 ml of fasting venous blood samples were collected from each diabetic patients and control group. Serum glucose, cholesterol and triglyceride were determined by enzymatic method and HbA1C was determined by quantitative colorimetric of glycohaemoglobin in whole blood measured spectrophotometrically . The results showed the higher incidence of diabetic patients in female( 82.6%) than male (17.4% ) . The result illustrate the high occurrence of type 2 diabetes at age 61-70 and 51-60 years which recorded 22.6% and 21.3% in female group while in male group the higher incidence at age 51-60years followed by 41-50 years old with percentage 9.3%, 5.3% respectively . Statistical analysis showed significant increase in systolic pressure(p<0.05) in diabetic patients . 38.6% of diabetic patients have overweight followed 32%are obese class-1-while only 4.6% have normal weight . Also the result showed increase in mean value of serum cholesterol and triglyceride which recorded 210 mg/dl and 176.5 mg /dl respectively compared to control group(p 0.01) . 9.3% of diabetic patients have polycystic ovary and 17.3% of them have family history of diabetes .The present study revealed increase in fasting plasma sugar concentration (273.3mg/dl) and ( HbA1c 8.9%) in diabetic group compared to control group (p 0.001) .The sensitivity and specificity and positive predictive value of HbA1c was reported 82%, 54% and 89% respectively. According to WHO classification of HbA1C in diabetic patients , the results indicated 73.3% of diabetic patients were poor control ,17.3% fair control and 9.3% were good control Conclusion:. HbA1c is not recommended as a diagnostic or a screening test while it is considered a marker of evaluation of long-term glycemic control in diabetic patients and predict risks for the development and progression of diabetic complications. Keywords: Diabetes mellitus, Glycaemic Control, HbA1c, fasting blood sugar.

Effect of Coca Cola Consumption on Urinary Crystals Formation and Some Blood Biochemical Parameters

Oct 15, 2016

Journal Diyala journal for pure science

Issue 4

Volume 12

Coca-Cola consumption has been widely distributed in recent years; therefore, the study aimed to detect the side effects of coca-Cola intake on urinary crystals formation and some blood biochemical parameters, including serum total calcium, ionized calcium, phosphorus, uric acid and albumin. Blood and urine samples were collected from healthy volunteers who were divided into three groups: group 1, who drank 1 can (200ml) of Coca-Cola daily. Group 2, who drink 2 cans or more (400ml) of Coca-Cola daily. These results were compared with the control group (group 3), which didn't drink soft beverages . All parameters were determined in blood samples using spectrophotometer while urine samples examined under the microscope. The results revealed a significant (p<0.01 ) increase in serum phosphorus, albumin and uric acid in groups 1 and 2 compared to the control group and a significant decrease in serum total, corrected and ionized calcium in group 2 compared to the control group. When comparing groups 1 and 2, the results revealed significant differences in serum total, corrected, and ionized calcium, as well as uric acid. Urine examination results appeared 39.1% of uric acid crystal and 30.4 % of amorphous urate crystals in group 1 while in group 2 drinking coca cola contribute to increased combined crystal formation which recorded uric acid with amorphous urate crystals 30% followed 15% of each Calcium oxalate with triple phosphate and Uric acid with triple phosphate.

A study of some blood biochemical parameters in blood serum of patients with chronic renal failure

Dec 16, 2013

Journal Journal of Basrah Researches ((Sciences))

Issue 4

Volume 39

This study was carried out on 55 patients(32males,23 females) with chronic renal failure aged 15-75) years admitted to al-dialysis unit in Kirkuk General Hospital which was compared with 35 healthy subjects as the control group .This study aims to investigate some biochemical parameters included urea, creatinine, uric acid, total protein, triglycerides, total calcium, inorganic phosphorus, magnesium, iron , total iron binding capacity and ferritin in the serum of patients with chronic renal failure (CRF)before and after hemodialysis and to detect body mass index(BMI) and serum glucose in patientsbefore dialysisonly . The results showed that there was significant increase(p<0.05) in the serum urea, creatinine ,uric acid ,triglyceride, magnesium and ferritin while revealed significant decrease in the levels oftotal protein, iron and total iron binding capacity inpatients before dialysis compared to the control group.Non-significant increase(p>0.05) is in serum glucose, phosphorus and body mass index in patients undergoing haemodialysis which was compared to the control group .There was non-significant decrease in the calcium in serum pre-dialysis patients than those in the control group. In comparative study between pre and post haemodialysiscases,the serum urea,creatinine ,uric acid ,triglyceride, inorganic phosphorus and magnesium level showed significant decrease (p<0.05)in post dialysis compared to pre-dialysis ,while there was significant increase (p<0.01)in the serum total protein ,calcium ,iron ,total iron binding capacity and ferritin in post dialysis compared to pre dialysis. No significant changes(p>0.05) were observed in the levels of magnesium, iron, total iron binding capacity and total protein whereas significant increase(p<0.01) observed in the levels of urea, creatinine, uric acid, triglyceride, inorganic phosphorus and ferritin in post dialysis compared with blood serum of normal individuals. There was a significant decrease in serum calcium in post-dialysis when compared with the control group. Keywords : chronic renal failure , hemodialysis, elements