Safaa Hashim Mohammed Albayati
Research Interests
| Gender | MALE |
|---|---|
| Place of Work | College of Health and Medical Techniques / Kirkuk |
| Position | Head of Graduate Studies Department |
| Qualification | Master |
| Speciality | Chemistry / analytic chemistry |
| safabayat@ntu.edu.iq | |
| Phone | 07729311702 |
| Address | كركوك حي الواسطي, Kirkuk, Kirkuk, Iraq |
Publications
Mesoporous silica and chitosan based pH-sensitive smart nanoparticles for tumor targeted drug delivery
Jul 29, 2017Journal Journal of Inclusion Phenomena and Macrocyclic Chemistry
publisher Pervin Deveci, Bilge Taner & Safaa Hashım Mohammed Albayatı
Issue 89
Volume .Springer
Although various therapies have been developed for cancer treatment, chemotherapy plays a vital role, but still faces many challenges, such as severe cytotoxicity, side effects, multidrug resistance, and poor tumor selectivity. The development of targeted drug delivery has provided new strategies for addressing the limitations of the conventional chemotherapy, and has become more significant in clinical research in recent times. Among the various stimuli, pH triggered delivery is regarded as the most general strategy, targeting the acidic extracellular microenvironment and intracellular organelles of solid tumors. It is well-known that the extracellular pH of most tumor tissues is more acidic (pH 6.5–6.8) than that of normal tissues (pH 7.4). In our present review, we focus on some of the recent literature reports on the fabrication and application of pH-sensitive smart nanoparticles for tumor targeted drug delivery system. The strategies to the chemical design of these nanocarriers and their clinical findings are discussed. Particular focus is given to silica, chitosan, and silica–chitosan based nanocarriers. These smart nanoparticles will have a promising platform in improving human health and quality of life.
pH and GSH dual responsive smart silica nanocarrier for doxorubicin delivery
Mar 20, 2019Journal Materials Research Express
publisher Safaa Hashım Mohammed Albayatı.Pervin Soylu
Issue 6
Volume IOPscience
Drug delivery system (DDs) should include stimuli-responsive release at the target sites. With this goal, pH and Glutathione (GSH) microenvironment triggering mesoporous silica nanoparticles (MSNs) were prepared. In this system, the ZnO Quantum Dots, as a gatekeeper is bonded to the silica nanocarrier via a cleavable disulfide bond. ZnO QDs have the potential to be used as a gatekeeper due to, its acidic dissolution to Zn 2+ ions. Doxorubicin hydrochloride (Dox), an effective chemotherapeutic drug, is used to investigate the release behavior. Under physiological pH, ZnO QDs is stable, which resulted in blocked drugs inside the pores. Under the acidic pH, grafted ZnO QDs is removed due to its acidic dissolution, which resulted in the pore opening and releasing of the drug. Besides pH stimuli, the release of the drug was triggered by GSH.
Butylated hydroxyanisole nanomolar detection using a molecularly imprinted electrochemical sensor in food samples
Oct 14, 2023Journal Journal of Applied Electrochemistry
publisher .Safaa Hashim Mohammed Albayati 2. Pervin Soylu
DOI 10.1007/s10800-023-01996-8
Issue 54
Volume Springer Netherlands
Detecting butylated hydroxyanisole (BHA) in food, and other substances is critical for human health, as it is poisonous to cells. In this study, o-phenylenediamine (o-PDA) was electropolymerized over a glassy carbon electrode (GCE) decorated with gold nanoparticles (GNPs) and multiwalled carbon nanotubes (MWCNTs) to construct an electrochemical sensor for BHA detection. The structural characterization of the produced sensor was analyzed using scanning electron microscopy (SEM), atomic force microscopy (AFM), differential pulse voltammetry (DPV), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS). Under ideal conditions, the linear response range of the proposed sensor was 0.01 µM to 5 µM and 5 µM to 1000 µM, with an ultra-low detection limit of 6 nM. Furthermore, the sensor demostrated excellent stability, selectivity, repeatability, and reproducibility. It was successfully used to detect BHA in mayonnaise, black cumin oil, and soybean oil, with recoveries ranging from 97.96% to 102.66% and relative standard deviations (RSDs) less than 2.11%, indicating that BHA detection in actual samples is both possible and accurate.
A novel molecularly imprinted electrochemical sensor for the ultrasensitive detection of tert-butylhydroquinone in edible oils
Dec 1, 2023Journal Analytical Biochemistry
publisher Safaa Hashım Mohammed Albayatı , Zafer Üstündağ , Pervin Soylu
DOI doi.org/10.1016/j.ab.2023.115348
Issue 682
Volume Elsevier
Tert-butylhydroquinone (TBHQ) is widely used to increase the stability of food products; however, it is considered to be a highly unsafe preservative ingredient that has caused serious damage to human health. Thus, in this paper, a novel molecularly imprinted electrochemical sensor was designed for ultrasensitive, and selective detection of TBHQ in edible oils. The sensor was based on the molecularly imprinted polymer (MIP) synthesized with multiwalled carbon nanotube (MWCNT), and gold nanoparticle (GNP), as the coating materials, o-phenylenediamine (o-PDA) as the functional monomer, and TBHQ as the template molecule. The electrochemical behavior of MIP/GNP/MWCNT/GCE was studied using several electrochemical methods, which showed a low detection limit of 5 nM. Furthermore the sensor demostrated excellent stability, selectivity, repeatability, and reproducibility. It was successfully used to detect TBHQ in edible oils, with recoveries ranging from 98.44% to 102.09% and relative standard deviations (RSDs) of less than 2.16%, indicating that TBHQ detection in actual samples is both possible and accurate.
A simple molecularly imprinted electrochemical sensor for determination of propyl gallate in food samples
Jan 29, 2024Journal Analytical Biochemistry
publisher Safaa Hashım Mohammed Albayatı. Pervin Soylu
DOI https://doi.org/10.1016/j.ab.2024.115477
Issue 688
Volume Elsevier
Propyl gallate (PG), a prevalent synthetic phenolic antioxidant found in food products, has generated considerable apprehension owing to its potential adverse impacts on human health. Therefore, as a result of the current inquiry, an innovative electrochemical sensor with improved sensitivity and selectivity for PG detection has been created. Under optimal conditions, the manufactured sensor exhibits the capability to identify PG within a broad range from 0.01 μM to 5 μM and from 5 μM to 1000 μM with a limit of detection (LOD) of 6 nM, demonstrating exceptional levels of reproducibility, repeatability, stability, and selectivity. The sensor demonstrated successful detection of PG in edible oils and mayonnaise, with good recoveries ranging from 98.44 % to 101.37 %.
A simple UiO-66-NH2@ MWCNTs-COOH based electrochemical sensor for the sensitive detection of tert-butylhydroquinone in edible oils
Oct 1, 2024Journal Microchemical Journal
publisher Pervin Soylu, Canan Başlak, Perihan Kılıçoğlu, İsmail Hikmet Kula, Mustafa Barış Koçer, Safaa Hashım Mohammed Albayatı
DOI https://doi.org/10.1016/j.microc.2024.111331
Issue 205
Volume Elsevier
The precise identification of tert-butylhydroquinone, a dangerous food preservative is critical for ensuring food quality and safety. In this study, a solvothermal method is used to combine carboxylated multiwalled carbon nanotube (MWCNTs-COOH) with UiO-66-NH2 to generate UiO-66-NH2@MWCNTs-COOH and its presence was confirmed using various characterization techniques such as UV–Vis, fluorescence spectra, FT-IR, SEM-EDX, XRD and XPS. Due to UiO-66-NH2@MWCNTs-COOH nanocomposite’s excellent electrocatalytic properties, it was chosen as the sensor material and integrated onto the bare glassy carbon electrode’s surface. Under optimal conditions, the manufactured electrochemical sensor demonstrated remarkable levels of repeatability, stability, selectivity, and reproducibility to detect throughout a wide range, ranging from 0.02 μM to 0.4 μM and 400 μM, while maintaining a 4 nM limit of detection In addition, the sensor’s usability was evaluated on samples of edible oil, resulting in an excellent recovery of tert-butylhydroquinone in the range of 98.45 % to −102.8 %. This work provides a simple, a faster, and an important methodology for utilizing UiO-66-NH2 in the electrochemical sensor area.