Evaluating the Potential of Annona muricata L. Plant Compounds as Reducing Agents for Toxicity of Ethylene Glycol

May 1, 2020

Journal Annals of Tropical Medicine & Public Health

DOI http://doi.org/10.36295/ASRO.2020.23931

Issue 9

Volume 23

Annona muricata L. is a tropical plant, which is considered as an attractive species due to its medical uses and bioactivity. This study evaluated the potential of Annonaplant for decreasing the toxic effect of ethylene glycol. Twenty five male rabbits were divided into five groups, i.e., control group (without any additives), group fed with ethylene glycol and the rest of groups were fed withAnnona muricata L. compounds (flavonoid, glycoside and alkaloids) to monitor its impact on liver activity. Results revealed that ethylene glycol increased the levels of aspartate transaminase, alanine transaminase, gamma glutamyltransferase and alkaline phosphatase, whereas Annona compounds decreased the toxicity of ethylene glycol.A significant difference (P˂ 0.05) in total protein, albumin, globulin values as well as A/G ratio was observed in the control group in comparison to ethylene glycol group and ethylene glycol groups with Annona muricata L. plant compounds. Lipid peroxidation resulted in high level of malondialdehyde in the ethylene glycol group in comparison to the control group, however, Annona compounds reduced the level of ethylene glycol, which in turn decreased the oxidative damage. Glutathione, catalase as well as glutathione peroxidase levels increased among the groups fed with Annona compounds in comparison to that fed with ethylene glycol only. Superoxide dismutase recorded approximately the same levels in all tested groups.There was a significant difference (P˂ 0.05) in MDA and CAT values in all groups, while no significant difference (P> 0.05) was observed in other parameters, i.e., GSH, GPx as well as SOD levels.

Assessing the Potential of Prolactin Hormonein Chronic Kidney Disease Patients

Apr 1, 2021

Journal Annals of R.S.C.B

Issue 4

Volume 25

Prolactin is a protein known as luteotropin, which enables mammals(females) to produce milk.This study evaluated the relationship between increasing prolactin levels and Chronic Kidney Disease (CKD). Blood sampleswere collected from 36patients with CKD and 35healthy people as a control group.Kidney function test was conducted, as the following parameters were calculated for both CKD patients and the control group: serum prolactin, insulin, insulin resistance, creatinine,glucose, uric acid,urea, albumin and total protein. Results showed that high levels of serum prolactin (57±3.21ng/dl) were observed in CKD patients in comparison to the control group (21±2.2 ng/dl). A significant difference (P˂0.05) was recorded in serum prolactin, insulin, insulin resistance, urea, creatinine and uric acid levelsbetweenCKD patients and the control group. Results also revealed that serum prolactin in CKD patients was higher in females (68±1.21ng/dl) than that recorded in males (47±3.22 ng/dl) in comparison to the control group for both males and females (19±1.2 and 23±2.4 ng/dl) respectively. Insulin resistance recorded nearly the same values in CKD patients for both males and females (5.99±1.12 and 6.39±0.51) respectively but higher than those recorded in the control group (2.79±0.31and3.07±0.31) respectively. Blood urea levels were considerably higher in males (81±3.11 mg/dl) than that recorded in females (72±3.11 mg/dl) for CKD patients in comparison to the control group for both males and females (15.8±2.1 and 14.3±3.1 mg/dl) respectively.

PROTECTIVE EFFECT OF MELILOTUS INDICUS L AGAINST HEPATIC INJURY STIMULATED BY CARBON TETRACHLORIDE IN MALE RABBITS

Jun 23, 2021

Journal Biochem. Cell. Arch

Issue 2

Volume 21

Melilotus indicus L. is an attractive plant for its medical applications, which is found in tropical regions. The current study tends to assess the potential of Melilotus plant for reducing the toxicity of CCl4 compound. Thirty male rabbits were placed into five groups, i.e., control group, group fed with CCl4 and the remain of groups were fed with Melilotus compounds (alkaloids, flavonoid and glycoside) to detect its effect on liver efficiency. Lipid peroxidation revealed increasing levels of malondialdehyde in the CCl4 group in comparison to the control group, however, Melilotus compounds decreased the level of CCl4 , which in turn reduced the oxidative destruction. Catalase, glutathione and glutathione peroxidase levels recorded high levels in the groups fed with Melilotus compounds in comparison with those fed only with CCl4 . Superoxide dismutase levels were about the same in all studied groups. There was a significant difference (P > 0.05) in CAT and MDA values across both groups, however, no significant difference (P < 0.05) was observed in other parameters such as GSH, GPx and SOD. CCl4 increased the levels of alanine transaminase, aspartate transaminase, alkaline phosphatase and gamma glutamyltransferase, while Melilotus compounds reduced the toxic effect of CCl4 . In contrast to the CCl4 group and the CCl4 groups fed with Melilotus plant compounds, there was a significant difference (P > 0.05) in albumin, total protein, globulin values and A/G ratio in the control group.

دراسة تاثير مستخلصات نباتات الاخيلية الالفية والميرامية والسنامكي في نمو الفطر Aspergillus ustus

Mar 7, 2013

Journal مجلة التربية والعلم

Issue 3

Volume 26

تاثير المستخلص الكحولي لاوراق نبات السنامكي والميرامية والاخيلية الالفية في نمو الفطر Aspergillus niger

Nov 16, 2011

Journal المؤتمر العلمي الثاني لعلوم الحياة/كلية العلوم/جامعة الموصل