Synthesis, Characterization and Biological Investigation of Some New Metal Complexes of Cu2+, Mn2+, Co2+, Zn2+ and Ni2+ ions with the Ligand of 2-[(8-hydroxy-1-quinolin-5-yl)- methyl]-1H-1,2-benzothiazole-3-(2H)-one-1,1-dioxide

Sep 14, 2015

Journal Kirkuk University Journal /Scientific Studies (KUJSS)

Issue 3

Volume 10

The synthesis, characterization and biological activity of new complexes of Cu2+, Mn2+, Co2+, Zn2+ and Ni2+ ions with derivatives ligand from N-hydroxy methyl saccharin and 8-hydroxy quinoline were described and studied. The new prepared complexes (ligands) were characterized by elemental analysis, molar conductance, IR, H1-NMR and C13-NMR spectroscopy studies. Coordination of the ligand atom to the metal ions was deduced by IR. All the complexes have been screened for antibacterial and antifungal.

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Synthesis, Characterization and Biological Investigation of Some New Hydroxy – 1,3,4 – Oxadiazole Derivatives

May 22, 2016

Journal Kirkuk University Journal /Scientific Studies (KUJSS)

DOI https://doi.org/10.32894/kujss.2016.124650

Issue 3

Volume 11

1,3,4 – Oxadiazole are important compounds because of its versatile biological action such as antimicrobial, antimalarial, anticonvulsant, hypoglycemic, also analgesic, anti – inflammatory and anticancer. In the present study the solid compounds of hydroxy 1,3,4 – oxadiazoles have been synthesized by reaction of acid hydrazides with CS2 in the presence of KOH. All the prepared compounds are characterized by using elemental analysis (C, H, N and S) and spectroscopic IR, H1 – NMR and studied the biological activity on four antibacterial (gram +Ve and gram –Ve) and three antifungal organisms.

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Synthesis Characterization of Some New Heterocyclic Compounds Containing1, 3-Oxazepine Ring

May 22, 2016

Journal Kirkuk University Journal /Scientific Studies (KUJSS)

Issue 3

Volume 11

In this work a series of 1, 3-oxazepine derivatives have been synthesized throughout two steps. First step synthesis of imines derivatives (A1-A7) via the condensation reaction of 4-hydroxy benzaldehyde with different substituted amines by using catalytic amount of glacial acetic acid, while the second step involves reactions of the prepared imines (A1-A7) via maleic anhydride by [2+5] cycloaddition in dry benzene and refluxing it to produce 1, 3 - oxazepine - 4, 7 - dione derivatives (A1m-A7m) respectively. The prepared compounds were characterized by C.H.N.S micro analysis, some physical properties and spectral methods (IR , H1-NMR).

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Synthesis, Characterization and Study of Biological Activity of Some 1, 3, 4 – Oxadiazole Derivatives and Complexes with Some Metals and Transition Metals

Apr 1, 2017

Journal Diyala Journal For Pure Sciences

DOI DOI: http://dx.doi.org/10.24237/djps.1302.209C

Issue 2

Volume 13

1,3,4 – Oxadiazole are important compounds because of its versatile biological action such as antimicrobial, antimalarial, anticonvulsant, hypoglycemic, also analgesic, anti – inflammatory and anticancer. In the present study some phenolic 1,3,4 – oxadiazoles derivatives and their complexes with some transition elements have been synthesized and characterized by using elemental analysis (C, H, N, S and M) and spectroscopic (IR, H1 – NMR and UV-Visible), magnetic study and molar conductivity. All the physical and spectral data give good evidence for the accuracy of the prepared compounds and all the prepared complexes gives a good effect to the types of normal and fungi bacteria’s

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Synthesis and Characterization of Some Metal Complexes with Mannich Bases Derived from Saccharin and Study their Biological Activity

Apr 1, 2017

Journal Diyala Journal For Pure Sciences

DOI DOI: http://dx.doi.org/10.24237/djps.1302.174C

Issue 2

Volume 13

A new series of transition metal complexes of Mn (II), Fe(II), Co(II), Ni(II) and Cu(II) have been synthesized from Mannich bases of ligands (J1) and (J2) that derived from saccharin and formaldehyde with 4-nitro aniline(J1) and 4-bromo aniline (J2).All the complexes are characterized by physical methods ( C.H.N.S micro analysis and molar conductivity) and spectral methods (IR, UV-Visible and H1-NMR). The results shows that the complexes of the [M(L)Cl2(H2O)] where M= Mn(II), Fe(II), Co(II), Ni(II) and Cu(II) are tetrahedral structure except copper complexes have a square planer geometry. The biological activity of these complexes are studied with (Staphylococcus aureus) that gives a good activity while the ligands absent any activity.

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Synthesis, Identification, and Antibacterial Effect Assessment of Some New 1,4-Thiazepines, Derived from Substituted Diphenyl Acrylamides and Diphenyl Dienones

May 17, 2023

Journal Chemical Methodologies

publisher Sami Publishing Company

DOI DOI:10.22034/CHEMM.2023.392659.1668

Issue 7

Volume 7

Some new 1,4-thiazepine derivatives (J16-J30) have been successfully synthesized through the reaction between each of diphenyl acryl amides (J1-J10) and diphenyl dienones (J11-J15) with ortho-mercapto aniline. The reaction was performed in an alkaline medium using ethanol as a solvent. The diphenyl acryl amides were prepared from the condensation reaction of para-substituted acetanilides with different para benzaldehydes, while para-substituted benzaldehydes were reacted with acetone to produce the diphenyl dienones. All the prepared compounds have been identified, using visible and ultraviolet radiation spectrum, and infrared spectrum. Some of the new synthesized compounds have been diagnosed and confirmed their structures by proton and carbon nuclear magnetic resonance spectrum (1H-NMR and 13C-NMR, respectively). The purity of prepared compounds was confirmed by relying on thin-layer chromatography (TLC) results. The biological effect of these derivatives was assessed against certain types of gram-positive bacteria (Streptococcus Pneumonia and Staphylococcus Aureus) and gram-negative bacteria (Escherichia Coli, Pseudomonas Aeruginosa, and Proteus Moralities). The results showed a high antibacterial effect towards both types of the used bacteria at high concentrations, while the prepared compounds behaved differently at low concentrations. The results indicated that most of new thiazepines revealed a high antibacterial effect towards both types of the tested bacteria at high concentrations (100 mg/mL), while behaved oppositely at low concentrations (10 and 50 mg/mL). This is related to high concentration effect resulting in an increase for inhibition zone diameter. The highest antibacterial effect was observed for compounds (J17, J19, J21, J24, J25, J26, J28, and J30) at 100 mg/mL. One of the reasons could be the presence of halogenes and nitro groups compared to t

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Synthesis, Characterization, and Antibacterial Activity Evaluation of Some New Benzoxazepindiones Obtained from Diphenylacrylimidamides

Nov 18, 2024

Journal Iran. J. Chem. Chem. Eng. (IJCCE)

publisher Sami Publishing Company

DOI 10.30492/ijcce.2024.2040353.6781

Issue 2

Volume 44

This study reports the synthesis of new 1,3-oxazepine derivatives (S21-S30) by reacting hydrazones (Schiff bases) (S11-S20) with phthalic anhydride in dry benzene as the solvent. The hydrazones were prepared by reacting diphenyl acrylamide derivatives (S1-S10) with para-chloroaniline using ethanol as the solvent. The acrylamides were derived from para-substituted acetanilides treated with various para-benzaldehydes using ethanol as the solvent. All synthesized compounds have been characterized using UV-Visible and FT-IR spectroscopy. The structure of chemicals has been confirmed using proton and carbon nuclear magnetic resonance spectroscopy (1H-NMR and 13C-NMR). The purity of the synthesized chemicals was confirmed through Thin-Layer Chromatography (TLC). The antibacterial activity of the new compounds has been assessed against gram-positive bacteria (Streptococcus Pneumoniae and Staphylococcus Aureus) and gram-negative bacteria (Pseudomonas Aeruginosa and Escherichia Coli). The results showed significant antimicrobial activity at varying concentrations, with compounds S23, S26, and S30 exhibiting the highest effectiveness attributed to the electron-withdrawing halogens present in their structures.

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Synthesis, Identification, and Antibacterial Effect Assessment of Some New 4,5-Dihydro-1H-Pyrazole Derived from Substituted Chalcones

Jan 24, 2025

Journal Chemistry & Chemical Technology

DOI 10.30492/ijcce.2024.2040353.6781

Issue 2 or 3

Volume 19

Synthesis and Characterization of New Thiazine Compounds Derivatized From 1-(Pyrazin-2-Yl)-3-(Benzylidene) Propanone and Study of Their Biological Effectiveness

May 1, 2025

Journal OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan

DOI DOI: https://doi.org/10.61132/obat.v3i3.1236

Issue 3

Volume 3

This study examines the synthesis and characterization of new compounds produced from chalcone, confirming their favorable yield and excellent purity utilizing Using FT-IR and 1H and 13C NMR spectroscopy. The compounds showed efficacy comparable to that of conventional antibiotics, demonstrating substantial bactericidal activity against Staphylococcus aureus and Escherichia coli. Interestingly, molecule S10 had stronger antibacterial activity, possibly as a result of its efficient electronic pairings. Furthermore, the compounds demonstrated resilience for up to 45 seconds when tested for stability under helium-neon laser irradiation. Longer exposure (60 seconds), however, caused discernible color and melting point alterations, suggesting thermal or photochemical deterioration. These results point to the possibility of additional pharmacological uses for molecules produced from chalcone.

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