Effect of Alcoholic Extract of Carrichtera annua Plant on the Growth of Leishmania donovani Parasite, In vitro Study

Apr 10, 2024

Journal Earth and Environmental Science

publisher Third Virtual International Conference on Environmental Sciences IOP

DOI 10.1088/1755-1315/1325/1/012027

Abstract. The current study was conducted to find out the efficacy of the alcohol extract of Al- Khashin plant Carrichtera annua plant in treating the Leishmania donovani parasite In vitro, where the concentration of 1.5 mg/ml resulted in an inhibitory effect on the growth of the promastigote of parasites at a percentage of 50% (LCD50) during 96 an hour at a rate of 38.1 x10³ cells / cm³ compared to the control treatment 76.2 x10³ cells / cm³, the results showed the significant inhibitory effect of the alcohol extract of Al-Khashin plant on the growth of Leishmania parasites, which led to a decrease in the number of generations and an increase in their time, as the number of generations reached 108.7 generation compared to the control treatment reached 232.5 generations using the same concentration within 96 hours of treatment, an inverse relationship was observed between increased concentration and generation time. The conclusion of the present study is the high efficiency of C. annua alcoholic extract in treating the L. donovani parasites as it led to an apparent inhibition of the growth of promastigote that was treated with different concentrations of the alcoholic extract of the plant

Effect of Alcoholic Extract of the Plant Conyza bonariensis on the Parasite Hymenolepis nana in Albino Mice Infected with it Experimentally

Jun 1, 2024

Journal Earth and Environmental Science

publisher Third Virtual International Conference on Environmental Sciences IOP

DOI 10.1088/1755-1315/1325/1/012026

Abstract. This study was conducted to investigate the effect of an alcoholic extract of the Mountain grass plant Conyza bonariensis on adults of the dwarf tapeworm Hymenolepis nana in albino mice infected with it experimentally, where Albino mice of the strain Balb / C were infected with these worms experimentally, it was divided into 5 groups, each group consisting of 6 rats, where the first group (control) was given distilled water only. As for the other groups, they were dosed with different concentrations of the alcoholic extract of the plant 50, 100, and 200 mg/kg, The last group was given 15 mg/kg of Niclosamide in one dose per day for 13 days. The results showed the effective effect of the concentrations of the alcoholic extract and the drug Niclosamide in the treatment of albino mice, and it produced a high therapeutic efficiency of 100%, with a variation in the period required for complete treatment and complete elimination of helminths, where the highest concentration of 200 mg/kg and the use of the drug led to a complete recovery of the infected Albino mice during the ninth day of treatment, and it was noted that the worm eggs disappeared from the swabs of the treated mice, while the infection continued in the control group until the thirteenth day, then died after that